Allopregnanolone restores hippocampal-dependent learning and memory and neural progenitor survival in aging 3xTgAD and nonTg mice

@article{Singh2012AllopregnanoloneRH,
  title={Allopregnanolone restores hippocampal-dependent learning and memory and neural progenitor survival in aging 3xTgAD and nonTg mice},
  author={Chanpreet Singh and Lifei Liu and Jun Ming Wang and Ronald W. Irwin and Roberta Diaz Brinton},
  journal={Neurobiology of Aging},
  year={2012},
  volume={33},
  pages={1493-1506}
}
We previously demonstrated that allopregnanolone (APα) increased proliferation of neural progenitor cells and reversed neurogenic and cognitive deficits prior to Alzheimer's disease (AD) pathology (Wang, J.M., Johnston, P.B., Ball, B.G., Brinton, R.D., 2005. The neurosteroid allopregnanolone promotes proliferation of rodent and human neural progenitor cells and regulates cell-cycle gene and protein expression. J. Neurosci. 25, 4706-4718; Wang, J.M., Singh, C., Liu, L., Irwin, R.W., Chen, S… CONTINUE READING
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