Allopregnanolone prevents memory impairment: effect on mRNA expression and enzymatic activity of hippocampal 3-α hydroxysteroid oxide-reductase.

@article{Escudero2012AllopregnanolonePM,
  title={Allopregnanolone prevents memory impairment: effect on mRNA expression and enzymatic activity of hippocampal 3-α hydroxysteroid oxide-reductase.},
  author={Carla Gimena Escudero and Sebastian M Casas and Fernando Alfredo Giuliani and Vanesa Bazzocchini and Sebastian Garc{\'i}a and Roberto F M Yunes and Ricardo Cabrera},
  journal={Brain research bulletin},
  year={2012},
  volume={87 2-3},
  pages={280-5}
}
In this work we investigated how the neurosteroid allopregnanolone can modulate learning and memory processes. For this purpose, we used ovariectomized (OVX) rats subcutaneously injected with oestradiol benzoate (E) alone or E and progesterone (P). Then, rats were injected in dorsal hippocampus with allopregnanolone or vehicle. Animals were tested in… CONTINUE READING