Allopregnanolone-mediated protective effects of progesterone on tributyltin-induced neuronal injury in rat hippocampal slices

@article{Ishihara2013AllopregnanolonemediatedPE,
  title={Allopregnanolone-mediated protective effects of progesterone on tributyltin-induced neuronal injury in rat hippocampal slices},
  author={Y. Ishihara and Tomohito Kawami and A. Ishida and T. Yamazaki},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2013},
  volume={135},
  pages={1-6}
}
  • Y. Ishihara, Tomohito Kawami, +1 author T. Yamazaki
  • Published 2013
  • Chemistry, Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
  • Increasing evidence shows that progesterone, a neuroactive steroid, has protective actions in central nervous system, but there is little evidence to show the protective mechanism of progesterone on neurotoxicity induced by environmental chemicals. In this study, we examined the effects of progesterone on neuronal injury induced by tributyltin (TBT) in rat hippocampal slices. Treatment with progesterone dose-dependently suppressed hippocampal neuronal injury induced by TBT. The neuroprotective… CONTINUE READING
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