Allopregnanolone enhancement of GABAergic transmission in rat medial preoptic area neurons.

@article{Uchida2002AllopregnanoloneEO,
  title={Allopregnanolone enhancement of GABAergic transmission in rat medial preoptic area neurons.},
  author={Soko Uchida and Eiichiro Noda and Yasuhiro Kakazu and Yoshihito Mizoguchi and Norio Akaike and Junichi Nabekura},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2002},
  volume={283 6},
  pages={E1257-65}
}
Gamma-aminobutyric acid (GABA)-mediated transmission in the medial preoptic area (MPOA) of the hypothalamus plays an important role in functions such as sex steroid hormone dynamics and control of body temperature. The action of allopregnanolone, the primary metabolite of progesterone, on GABAergic transmission was investigated by employing patch clamp whole cell recording on acutely dissociated rat MPOA neurons with the functional connection of presynaptic terminals. Allopregnanolone enhanced… CONTINUE READING