Allopregnanolone concentration and mood—a bimodal association in postmenopausal women treated with oral progesterone
@article{Andren2006AllopregnanoloneCA, title={Allopregnanolone concentration and mood—a bimodal association in postmenopausal women treated with oral progesterone}, author={L. Andr{\'e}en and I. Sundstr{\"o}m-Poromaa and M. Bixo and S. Nyberg and T. B{\"a}ckstr{\"o}m}, journal={Psychopharmacology}, year={2006}, volume={187}, pages={209-221} }
RationaleAllopregnanolone effects on mood in postmenopausal women are unclear thus far.ObjectivesAllopregnanolone is a neuroactive steroid with contradictory effects. Anaesthetic, sedative, and anxiolytic as well as aggressive and anxiogenic properties have been reported. The aim of this study is to compare severity of negative mood between women receiving different serum allopregnanolone concentrations during progesterone treatment.Materials and methodsA randomized, placebo-controlled, double… CONTINUE READING
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References
SHOWING 1-10 OF 67 REFERENCES
Relationship between allopregnanolone and negative mood in postmenopausal women taking sequential hormone replacement therapy with vaginal progesterone
- Psychology, Medicine
- Psychoneuroendocrinology
- 2005
- 95
- PDF
Estradiol and the addition of progesterone increase the sensitivity to a neurosteroid in postmenopausal women
- Medicine
- Psychoneuroendocrinology
- 2005
- 20
The impact of different doses of medroxyprogesterone acetate on mood symptoms in sequential hormonal therapy
- Medicine
- Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
- 2002
- 68
- PDF
Increase of estrogen dose deteriorates mood during progestin phase in sequential hormonal therapy.
- Medicine
- The Journal of clinical endocrinology and metabolism
- 2003
- 67
- PDF
Progesterone effects during sequential hormone replacement therapy.
- Medicine
- European journal of endocrinology
- 2003
- 56
- PDF
Pharmacokinetic and behavioral effects of allopregnanolone in healthy women
- Medicine
- Psychopharmacology
- 2005
- 117
- PDF
Circulating levels of allopregnanolone in humans: gender, age, and endocrine influences.
- Medicine
- The Journal of clinical endocrinology and metabolism
- 1998
- 348
- Highly Influential
- PDF
Differential behavioral effects of gonadal steroids in women with and in those without premenstrual syndrome.
- Medicine
- The New England journal of medicine
- 1998
- 591
The effects of norethisterone in postmenopausal women on oestrogen replacement therapy: a model for the premenstrual syndrome
- Medicine
- British journal of obstetrics and gynaecology
- 1986
- 204
- Highly Influential
Negative mood changes during hormone replacement therapy: a comparison between two progestogens.
- Medicine
- American journal of obstetrics and gynecology
- 2000
- 92