Allopregnanolone concentration and mood—a bimodal association in postmenopausal women treated with oral progesterone

@article{Andren2006AllopregnanoloneCA,
  title={Allopregnanolone concentration and mood—a bimodal association in postmenopausal women treated with oral progesterone},
  author={Lotta Andr{\'e}en and Inger Sundstr{\"o}m-Poromaa and Marie Bixo and Sigrid Nyberg and Torbj{\"o}rn B{\"a}ckstr{\"o}m},
  journal={Psychopharmacology},
  year={2006},
  volume={187},
  pages={209-221}
}
RationaleAllopregnanolone effects on mood in postmenopausal women are unclear thus far.ObjectivesAllopregnanolone is a neuroactive steroid with contradictory effects. Anaesthetic, sedative, and anxiolytic as well as aggressive and anxiogenic properties have been reported. The aim of this study is to compare severity of negative mood between women receiving different serum allopregnanolone concentrations during progesterone treatment.Materials and methodsA randomized, placebo-controlled, double… 
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69 Citations

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TLDR
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Allopregnanolone, a GABAA receptor agonist, decreases gonadotropin levels in women. A preliminary study

TLDR
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...

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