Allopregnanolone concentration and mood—a bimodal association in postmenopausal women treated with oral progesterone

  title={Allopregnanolone concentration and mood—a bimodal association in postmenopausal women treated with oral progesterone},
  author={L. Andr{\'e}en and I. Sundstr{\"o}m-Poromaa and M. Bixo and S. Nyberg and T. B{\"a}ckstr{\"o}m},
  • L. Andréen, I. Sundström-Poromaa, +2 authors T. Bäckström
  • Published 2006
  • Medicine, Psychology
  • Psychopharmacology
  • RationaleAllopregnanolone effects on mood in postmenopausal women are unclear thus far.ObjectivesAllopregnanolone is a neuroactive steroid with contradictory effects. Anaesthetic, sedative, and anxiolytic as well as aggressive and anxiogenic properties have been reported. The aim of this study is to compare severity of negative mood between women receiving different serum allopregnanolone concentrations during progesterone treatment.Materials and methodsA randomized, placebo-controlled, double… CONTINUE READING
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