Allopregnanolone and mood disorders

@article{Bckstrm2014AllopregnanoloneAM,
  title={Allopregnanolone and mood disorders},
  author={Torbj{\"o}rn B{\"a}ckstr{\"o}m and Marie Bixo and Maja Johansson and Sigrid Nyberg and Lindsey Ossewaarde and Gianna Ragagnin and Ivanka Savic and Jessica Str{\"o}mberg and Erika Timby and Frank van Broekhoven and Guido A. van Wingen},
  journal={Progress in Neurobiology},
  year={2014},
  volume={113},
  pages={88-94}
}
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GABAA Receptor-Modulating Steroids in Relation to Women’s Behavioral Health
TLDR
In certain women, increased negative mood relates to the progesterone metabolite, allopregnanolone (allo), during the luteal phase of ovulatory menstrual cycles, the premenstrual dysphoric disorder (PMDD), and this effect can be induced by all GABAA receptor modulators in low concentrations whereas higher concentrations are calming.
Effects of GABA active steroids in the female brain with a focus on the premenstrual dysphoric disorder
TLDR
The underlying studies of this review provide evidence that allopregnanolone is the provoking factor behind the negative mood symptoms in PMDD and that isoallopreg nanolone could ameliorate the symptoms as a result of its ability to antagonise the allopreginolone effect on the GABAA receptor.
Women with premenstrual dysphoric disorder have altered sensitivity to allopregnanolone over the menstrual cycle compared to controls—a pilot study
TLDR
The effect of exogenous allopregnanolone is associated with menstrual cycle phase in PMDD patients and in controls, and the results suggest an altered sensitivity to allopreginolone in PM DD patients.
Polycystic Ovary Syndrome, Affective Symptoms, and Neuroactive Steroids: a Focus on Allopregnanolone
TLDR
Prospective studies evaluating associations between psychiatric symptoms and NAS are needed to elucidate the biological causes of the increased rates of psychiatric symptoms among women with PCOS and inform clinical treatment, and allopregnanolone, with its role in normal reproductive function, menstrual dysregulation, makes it a particularly intriguing candidate for future investigation.
Response to sertraline is associated with reduction in anxiety-potentiated startle in premenstrual dysphoric disorder.
TLDR
Altered alterations in APS suggest potential GABA-A-R changes across the menstrual cycle and in response to sertraline among treatment responders, suggesting impaired ability to modulate arousal reactivity.
Allopregnanolone and reproductive psychiatry: an overview
TLDR
An overview of the relationship between allopregnanolone and mood at menarche, in the menstrual cycle; in the peripartum; and in the menopausal transition finds ALLO dysregulation is identified in all of these transitions and found to be associated with mood symptoms.
The role of ovarian hormone-derived neurosteroids on the regulation of GABAA receptors in affective disorders
TLDR
GABAAR plasticity associated with alterations in neurosteroid levels represents a homeostatic compensatory mechanism to maintain an ideal level of inhibition to offset the potentiating effects of neurosteroids on GABAergic inhibition.
Hormonal Contraception and Depression: Updated Evidence and Implications in Clinical Practice
TLDR
An update of the literature on the possible appearance of depressive symptoms when using hormonal contraceptives is provided, and the possible explanations of this problem are investigated based on animal and human studies.
Progesterone, reproduction, and psychiatric illness.
Circulating steroids and mood disorders in patients with polycystic ovary syndrome
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