Alloimmunization to platelet antigen HPA-1a (PIA1) is strongly associated with both HLA-DRB3*0101 and HLA-DQB1*0201.

@article{LAbb1992AlloimmunizationTP,
  title={Alloimmunization to platelet antigen HPA-1a (PIA1) is strongly associated with both HLA-DRB3*0101 and HLA-DQB1*0201.},
  author={D L'Abb{\'e} and Lorraine Norah Tremblay and Martin Filion and Lambert Busque and M Goldman and Francine D{\'e}cary and Pascal Chartrand},
  journal={Human immunology},
  year={1992},
  volume={34 2},
  pages={107-14}
}
Antibodies to the platelet HPA-1a antigen can elicit in the newborn a condition known as neonatal alloimmune thrombocytopenic purpura (NAITP). Previous studies based on RFLP analysis showed that 100% of HPA-1a-negative women who produced anti-HPA-1a antibodies (responders) were HLA-DRw52a (DRB3*0101). However, this specificity could also be found in some HPA-1a-negative women not producing anti-HPA-1a antibodies (nonresponders). We have analyzed in detail by PCR-SSOP the HLA-DR, -DQ, and -DP… CONTINUE READING

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[Platelet immunology and the immune response].

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