Allograft dendritic cell p40 homodimers activate donor-reactive memory CD8+ T cells.

@article{Tsuda2018AllograftDC,
  title={Allograft dendritic cell p40 homodimers activate donor-reactive memory CD8+ T cells.},
  author={Hidetoshi Tsuda and Charles A. Su and Toshiaki Tanaka and Katayoun Ayasoufi and Booki Min and Anna N Valujskikh and Robert L. Fairchild},
  journal={JCI insight},
  year={2018},
  volume={3 4}
}
Recipient endogenous memory T cells with donor reactivity pose an important barrier to successful transplantation and costimulatory blockade-induced graft tolerance. Longer ischemic storage times prior to organ transplantation increase early posttransplant inflammation and negatively impact early graft function and long-term graft outcome. Little is known… CONTINUE READING