Allogenic stem cell therapy improves right ventricular function by improving lung pathology in rats with pulmonary hypertension.

@article{Umar2009AllogenicSC,
  title={Allogenic stem cell therapy improves right ventricular function by improving lung pathology in rats with pulmonary hypertension.},
  author={Soban Umar and Yvonne P de Visser and Paul Steendijk and Cindy I. Schutte and El Houari Laghmani and Gerry T. M. Wagenaar and Wilhelmina H. Bax and Eleni Mantikou and Daniel A Pijnappels and Douwe Ekke Atsma and Martin Jan Schalij and E. E. van der Wall and Arnoud van der Laarse},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2009},
  volume={297 5},
  pages={H1606-16}
}
Pulmonary arterial hypertension (PAH) is a chronic lung disease that leads to right ventricular (RV) hypertrophy (RVH), remodeling, and failure. We tested treatment with bone marrow-derived mesenchymal stem cells (MSCs) obtained from donor rats with monocrotaline (MCT)-induced PAH to recipient rats with MCT-induced PAH on pulmonary artery pressure, lung pathology, and RV function. This model was chosen to mimic autologous MSC therapy. On day 1, PAH was induced by MCT (60 mg/kg) in 20 female… CONTINUE READING

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