Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects.

@article{Melenhorst2010AllogeneicVT,
  title={Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects.},
  author={J. Melenhorst and A. Leen and C. Bollard and Maire F Quigley and D. Price and C. Rooney and M. Brenner and A. Barrett and H. Heslop},
  journal={Blood},
  year={2010},
  volume={116 22},
  pages={
          4700-2
        }
}
  • J. Melenhorst, A. Leen, +6 authors H. Heslop
  • Published 2010
  • Medicine
  • Blood
  • Adoptive transfer of viral antigen-specific memory T cells can reconstitute antiviral immunity, but in a recent report a majority of virus-specific cytotoxic T-lymphocyte (CTL) lines showed in vitro cross-reactivity against allo-human leukocyte antigen (HLA) molecules as measured by interferon-γ secretion. We therefore reviewed our clinical experience with adoptive transfer of allogeneic hematopoietic stem cell transplantation donor-derived virus-specific CTLs in 153 recipients, including 73… CONTINUE READING
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 20 REFERENCES
    Allo-HLA reactivity of virus-specific memory T cells is common.
    • 237
    Graft-versus-host disease
    • 772
    • PDF