Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects.

@article{Melenhorst2010AllogeneicVT,
  title={Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects.},
  author={Jan Joseph Melenhorst and Ann M. Leen and Catherine M. Bollard and M{\'a}ire F. Quigley and David A. Price and Cliona M Rooney and Malcolm K. Brenner and A. J. Barrett and Helen E Heslop},
  journal={Blood},
  year={2010},
  volume={116 22},
  pages={
          4700-2
        }
}
Adoptive transfer of viral antigen-specific memory T cells can reconstitute antiviral immunity, but in a recent report a majority of virus-specific cytotoxic T-lymphocyte (CTL) lines showed in vitro cross-reactivity against allo-human leukocyte antigen (HLA) molecules as measured by interferon-γ secretion. We therefore reviewed our clinical experience with adoptive transfer of allogeneic hematopoietic stem cell transplantation donor-derived virus-specific CTLs in 153 recipients, including 73… CONTINUE READING
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