Allogeneic stimulation of cytotoxic T cells by supported planar membranes.

  title={Allogeneic stimulation of cytotoxic T cells by supported planar membranes.},
  author={A. Larsan Aro Brian and H. M. Mcconnell},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={81 19},
Phospholipid vesicles containing the transmembrane protein H-2Kk spontaneously fuse to form planar membranes when incubated on treated glass surfaces. Pattern photobleaching of fluorescent lipid probes indicates that these planar membranes are continuous and that the lipids are as mobile as they are in conventional fluid bilayers or monolayers. H-2Kk molecules in these planar membranes are immobile. These membranes stimulate cytotoxic T lymphocytes when cultured with immune spleen cells. The… CONTINUE READING
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