Allogeneic stem-cell transplantation with reduced conditioning intensity as a novel immunotherapy and antiviral therapy for adult T-cell leukemia/lymphoma.

@article{Okamura2005AllogeneicST,
  title={Allogeneic stem-cell transplantation with reduced conditioning intensity as a novel immunotherapy and antiviral therapy for adult T-cell leukemia/lymphoma.},
  author={Jun Okamura and Atae Utsunomiya and Ryuji Tanosaki and Naokuni Uike and Shunro Sonoda and Mari Kannagi and Masao Tomonaga and M. D. N. Harada and Nobuhiro Kimura and Masato Masuda and Fumio Kawano and Yuji Yufu and Hiroyoshi Hattori and Hiroshi Kikuchi and Yoshio Saburi},
  journal={Blood},
  year={2005},
  volume={105 10},
  pages={4143-5}
}
Sixteen patients with adult T-cell leukemia/lymphoma (ATL) who were all over 50 years of age underwent allogeneic stem cell transplantation with reduced-conditioning intensity (RIST) from HLA-matched sibling donors after a conditioning regimen consisting of fludarabine (180 mg/m2), busulfan (8 mg/kg), and rabbit antithymocyte globulin (5 mg/kg). The observed regimen-related toxicities and nonhematologic toxicities were all found to be acceptable. Disease relapse was the main cause of treatment… CONTINUE READING

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