Allogeneic stem cell transplantation improves the outcome of adults with t(1;19)/E2A-PBX1 and t(4;11)/MLL-AF4 positive B-cell acute lymphoblastic leukemia: results of the prospective multicenter LALA-94 study

@article{Vey2006AllogeneicSC,
  title={Allogeneic stem cell transplantation improves the outcome of adults with t(1;19)/E2A-PBX1 and t(4;11)/MLL-AF4 positive B-cell acute lymphoblastic leukemia: results of the prospective multicenter LALA-94 study},
  author={Norbert Vey and X. Thomas and Christophe Picard and T Kovascovicz and C Charin and J M Cayuela and Herv{\'e} Dombret and Nicole Dastugue and Françoise Huguet and Christian Bastard and Aspasia Stamatoulas and Michel Giollant and Olivier Tournilhac and Elizabeth A Macintyre and Agn{\'e}s Buzyn and Dominique Bories and Mathieu Kuentz and François J Dreyfus and Andr{\'e} Delannoy and Sophie Raynaud and Nicole Gratecos and Dominique Bordessoule and St{\'e}phane de Botton and Claude Joseph Preudhomme and Oum{\'e}daly Reman and Xavier Troussard and Arnaud Pigneux and C Bilhou and J. P. Vernant and Claude Boucheix and Jean Gabert},
  journal={Leukemia},
  year={2006},
  volume={20},
  pages={2155-2161}
}
Adult patients with acute lymphoblastic leukemia (ALL) and t(1;19)/E2A-PBX1 or t(4;11)/MLL-AF4 have a poor outcome. We have evaluated the impact of an intensified post-remission therapy using a high-dose chemotherapy course followed by allogeneic or autologous SCT on the outcome of 58 patients with t(1;19)/E2A-PBX1 (E2A group, n=24) or t(4;11)/MLL-AF4 (MLL group, n=34) treated in the LALA-94 multicenter prospective study. Patients in the MLL group had higher WBC counts and more frequent DIC. CR… CONTINUE READING
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References

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Showing 1-10 of 38 references

Outcome of treatment in adults with acute lymphoblastic leukemia: analysis of the LALA-94 trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2004

– a Europe Against Cancer program

MC Bene, G Castoldi, +3 authors A Orfao
2003