Allogeneic mesenchymal stem cells restore cardiac function in chronic ischemic cardiomyopathy via trilineage differentiating capacity.

@article{Quevedo2009AllogeneicMS,
  title={Allogeneic mesenchymal stem cells restore cardiac function in chronic ischemic cardiomyopathy via trilineage differentiating capacity.},
  author={Henry C Quevedo and Konstantinos E. Hatzistergos and Behzad N. Oskouei and Gary S Feigenbaum and Jose Eduardo Chorres Rodriguez and David Valdes and Pradip M. Pattany and Juan Pablo Zambrano and Qinghua Hu and I K Mcniece and Alan W. Heldman and Joshua M Hare},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 33},
  pages={14022-7}
}
The mechanism(s) underlying cardiac reparative effects of bone marrow-derived mesenchymal stem cells (MSC) remain highly controversial. Here we tested the hypothesis that MSCs regenerate chronically infarcted myocardium through mechanisms comprising long-term engraftment and trilineage differentiation. Twelve weeks after myocardial infarction, female swine received catheter-based transendocardial injections of either placebo (n = 4) or male allogeneic MSCs (200 million; n = 6). Animals… CONTINUE READING
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Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases

  • RK Burt
  • JAMA
  • 2008
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