Allogeneic lymphocyte-licensed DCs expand T cells with improved antitumor activity and resistance to oxidative stress and immunosuppressive factors

@inproceedings{Ramachandran2014AllogeneicLD,
  title={Allogeneic lymphocyte-licensed DCs expand T cells with improved antitumor activity and resistance to oxidative stress and immunosuppressive factors},
  author={Mohanraj Ramachandran and Di Yu and Victoria Hillerdal and Annacarin Wallgren and Jing Fan Ma and Magnus Essand},
  booktitle={Molecular therapy. Methods & clinical development},
  year={2014}
}
Adoptive T-cell therapy of cancer is a treatment strategy where T cells are isolated, activated, in some cases engineered, and expanded ex vivo before being reinfused to the patient. The most commonly used T-cell expansion methods are either anti-CD3/CD28 antibody beads or the "rapid expansion protocol" (REP), which utilizes OKT-3, interleukin (IL)-2, and irradiated allogeneic feeder cells. However, REP-expanded or bead-expanded T cells are sensitive to the harsh tumor microenvironment and… CONTINUE READING
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