Allogeneic hematopoietic stem cell transplantation for sickle cell disease: the time is now.

@article{Hsieh2011AllogeneicHS,
  title={Allogeneic hematopoietic stem cell transplantation for sickle cell disease: the time is now.},
  author={Matthew M Hsieh and Courtney D Fitzhugh and John F. Tisdale},
  journal={Blood},
  year={2011},
  volume={118 5},
  pages={
          1197-207
        }
}
Although sickle cell disease (SCD) has a variable clinical course, many patients develop end-organ complications that are associated with significant morbidity and early mortality. Myeloablative allogeneic HSCT (allo-HSCT) is curative but has been historically performed only in children younger than 16 years of age. Modest modifications in the conditioning regimen and supportive care have improved outcome such that the majority of children with a suitable HLA-matched sibling donor can expect a… CONTINUE READING
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