Allogeneic MHC antigen requirements for lupus-like autoantibody production and nephritis in murine graft-vs-host disease.

@article{Portanova1988AllogeneicMA,
  title={Allogeneic MHC antigen requirements for lupus-like autoantibody production and nephritis in murine graft-vs-host disease.},
  author={Joseph P. Portanova and Fanny M. Ebling and William S. Hammond and Bevra Hannahs Hahn and Brian L. Kotzin},
  journal={Journal of immunology},
  year={1988},
  volume={141 10},
  pages={3370-6}
}
A graft-vs-host (GVH) reaction of parental T cells in allogeneic F1 mice can lead to an autoimmune disease resembling human SLE. We analyzed the contribution of MHC genes to the development of IgG antinuclear antibody production and immune complex glomerulonephritis in MHC-congenic F1 recipients. DBA/2 T cells elicited IgG antibodies to histone, ssDNA, and dsDNA in all histoincompatible F1 recipients that were studied. The anti-DNA antibody responses were quantitatively similar among the F1… CONTINUE READING

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