Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome

@article{Hofstetter2005AllodyniaLT,
  title={Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome},
  author={C. Hofstetter and N. Holmstr{\"o}m and J. Lilja and P. Schweinhardt and J. Hao and C. Spenger and Z. Wiesenfeld‐Hallin and S. Kurpad and J. Fris{\'e}n and L. Olson},
  journal={Nature Neuroscience},
  year={2005},
  volume={8},
  pages={346-353}
}
Several studies have reported functional improvement after transplantation of neural stem cells into injured spinal cord. We now provide evidence that grafting of adult neural stem cells into a rat thoracic spinal cord weight-drop injury improves motor recovery but also causes aberrant axonal sprouting associated with allodynia-like hypersensitivity of forepaws. Transduction of neural stem cells with neurogenin-2 before transplantation suppressed astrocytic differentiation of engrafted cells… Expand
Pain inhibition through transplantation of fetal neuronal progenitors into the injured spinal cord in rats
Review of transplantation of neural stem/progenitor cells for spinal cord injury
  • A. Mothe, C. Tator
  • Medicine
  • International Journal of Developmental Neuroscience
  • 2013
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2
3
4
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References

SHOWING 1-10 OF 56 REFERENCES
Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery
Transplantation of glial cells enhances action potential conduction of amyelinated spinal cord axons in the myelin-deficient rat.
...
1
2
3
4
5
...