Allodynia and Hyperalgesia in Adjuvant-Induced Arthritic Rats: Time Course of Progression and Efficacy of Analgesics

  title={Allodynia and Hyperalgesia in Adjuvant-Induced Arthritic Rats: Time Course of Progression and Efficacy of Analgesics},
  author={Yukinori Nagakura and Masamichi Okada and Atsuyuki Kohara and Tetsuo Kiso and Takashi Toya and Akihiko Iwai and Fumikazu Wanibuchi and Tokio Yamaguchi},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={490 - 497}
The complete Freund's adjuvant (CFA)-induced arthritic rat model has extensively served as a laboratory model in the study of arthritic pain. However, the time courses of allodynia and hyperalgesia and the efficacies of different analgesics have not fully been analyzed in this model. Mechanical allodynia, thermal and joint hyperalgesia, and other disease development parameters (body weight, mobility, paw volume, and joint stiffness) were measured on postinoculation days (PIDs) 0 to 28 in rats… 

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