Allocation concealment and blinding: when ignorance is bliss

@article{Forder2005AllocationCA,
  title={Allocation concealment and blinding: when ignorance is bliss},
  author={Peta M Forder and Val Gebski and Anthony C. Keech},
  journal={Medical Journal of Australia},
  year={2005},
  volume={182}
}
NHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW. Peta M Forder, BSc, MPH, Statistician; Val J Gebski, BA, MStat, Associate Professor, and Senior Research Fellow; Anthony C Keech, FRACP, MScEpid, Deputy Director. Reprints will not be available from the authors. Correspondence: Associate Professor Anthony C Keech, NHMRC Clinical Trials Centre, University of Sydney, Locked Bag 77, Camperdown, Sydney, NSW 1450. enquiry@ctc.usyd.edu.au The Medical Journal of Australia ISSN: 0025729X… Expand

Topics from this paper

Allocation concealment and blinding: when ignorance is bliss
  • H. Hemilä
  • Psychology, Medicine
  • The Medical journal of Australia
  • 2005
It seems that even the ancients explored the intrinsic conflict between caring and commerce in medicine. Today, the relevance of this conflict has grown, as commercialism and its culture of creatingExpand
Allocation concealment and blinding: when ignorance is bliss
  • V. Berger
  • Psychology, Medicine
  • The Medical journal of Australia
  • 2005
It seems that even the ancients explored the intrinsic conflict between caring and commerce in medicine. Today, the relevance of this conflict has grown, as commercialism and its culture of creatingExpand
Allocation concealment and blinding: when ignorance is bliss
It seems that even the ancients explored the intrinsic conflict between caring and commerce in medicine. Today, the relevance of this conflict has grown, as commercialism and its culture of creatingExpand
Allocation concealment: a methodological review.
TLDR
It is highlighted that research needs to be reported to a higher standard and there are many trials reporting poor methods of allocation concealment within the small sample of trials included in this review. Expand
Exploring engagement with authors of randomised controlled trials to develop recommendations to improve allocation concealment implementation and reporting
Background: Reviews have consistently shown that allocation concealment is frequently implemented and reported suboptimally in randomised controlled trials (RCTs). This research aims to pilotExpand
Eliminating bias in randomized controlled trials: importance of allocation concealment and masking.
TLDR
Both allocation concealment and masking add to the elimination of bias in randomized controlled trials. Expand
Methodological Reporting Quality of Randomized Controlled Trials in 3 Leading Diabetes Journals From 2011 to 2013 Following CONSORT Statement
TLDR
This study shows that methodological reporting quality of RCTs in the major diabetes journals remains suboptimal and can be further improved to meet and keep up with the standards of the CONSORT statement. Expand
Glossary for randomized clinical trials.
TLDR
The aim of the current paper is to present a comprehensive glossary of the terminology used in randomized clinical trials in order to assist authors when designing, executing and writing-up randomizedclinical trials. Expand
Mechanisms and direction of allocation bias in randomised clinical trials
TLDR
Inadequate allocation concealment may exaggerate treatment effects in some trials while underestimate effects in others, and the hypothesis provides a theoretical overview of the main factors responsible for the direction of allocation bias. Expand
Randomization, Allocation Concealment, and Blinding
TLDR
This chapter provides definitions and describes the various methods of randomization, allocation concealment, and blinding that can be adopted in N-of-1 trials and details the roles of specific research staff and the information required for the reporting of N- of-1 trial blinding methods in medical journals. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 17 REFERENCES
Allocation concealment in randomised trials: defending against deciphering
TLDR
Investigators must effectively immunise trials against selection and confounding biases with proper allocation concealment, andHypothesis tests of baseline characteristics, however, are superfluous and could be harmful if they lead investigators to suppress reporting any baseline imbalances. Expand
The Revised CONSORT Statement for Reporting Randomized Trials: Explanation and Elaboration
TLDR
The CONSORT statement (or simply CONSORT) comprises a checklist of essential items that should be included in reports of RCTs and a diagram for documenting the flow of participants through a trial, aimed at first reports of two-group parallel designs. Expand
Size and quality of randomised controlled trials in head injury: review of published studies
Abstract Objective: To assess whether trials in head injury are large enough to avoid moderate random errors and designed to avoid moderate biases. Design: All randomised controlled trials on theExpand
The unpredictability paradox: review of empirical comparisons of randomised and non-randomised clinical trials
TLDR
On average, failure to use randomisation or adequate concealment of allocation resulted in larger estimates of effect due to a poorer prognosis in non-randomlyselected control groups compared with randomly selected control groups. Expand
Randomisation in clinical trials.
TLDR
Adequacy of the reporting of the procedure of randomisation in clinical trials of parallel design published in the British Journal of Psychiatry (BJP) and the American Journal of psychiatry (AJP) is examined. Expand
Assessing the quality of randomization from reports of controlled trials published in obstetrics and gynecology journals.
TLDR
Proper randomization is required to generate unbiased comparison groups in controlled trials, yet the reports in these journals usually provided inadequate or unacceptable information on treatment allocation, suggesting that nonrandom manipulation of comparison groups and selective reporting of baseline comparisons may have occurred. Expand
Blinding in randomised trials: hiding who got what
TLDR
Although double blinding (blinding investigators, participants, and outcome assessors) indicates a strong design, trials that are not double blinded should not automatically be deemed inferior, and researchers should explicitly state who was blinded, and how. Expand
The Landscape and Lexicon of Blinding in Randomized Trials
TLDR
The landscape and lexicon of blinding in randomized trials in the hope of untangling some of that terminology, which is widely recognized as reducing differential assessment of outcomes of interest. Expand
Randomised trials comparing chemotherapy regimens for advanced non-small cell lung cancer: biases and evolution over time.
TLDR
Increased reported median survival was independently associated with platinum and/or taxane and combination regimens, but also with the year of publication, smaller sample size, and larger representation of non-stage IV patients and patients with a better performance status. Expand
A randomized, controlled trial of aspirin in persons recovered from myocardial infarction.
  • Medicine
  • JAMA
  • 1980
TLDR
Based on AMIS results, aspirin is not recommended for routine use in patients who have survived an myocardial infarction and should not be used in routine practice. Expand
...
1
2
...