Alloantigen specific CD8+CD28- FOXP3+ T suppressor cells induce ILT3+ ILT4+ tolerogenic endothelial cells, inhibiting alloreactivity.

@article{Manavalan2004AlloantigenSC,
  title={Alloantigen specific CD8+CD28- FOXP3+ T suppressor cells induce ILT3+ ILT4+ tolerogenic endothelial cells, inhibiting alloreactivity.},
  author={John Sanil Manavalan and Seunghee Kim-Schulze and Luigi Scotto and Afzal Jamal Naiyer and George Vlad and Paolo Colombo and Charles Marboe and Donna Mancini and Raffaello Cortesini and Nicole Suciu-Foca},
  journal={International immunology},
  year={2004},
  volume={16 8},
  pages={1055-68}
}
Endothelial cells have been shown to activate T cell responses to alloantigens, triggering transplant rejection. However, they may also play a role in tolerance induction. Using RT-PCR we show here that alloantigen specific CD8(+)CD28(-) T suppressor cells generated in vitro are FOXP3 positive and interact with human endothelial cells. This interaction results in the induction of inhibitory receptors and down-regulation of costimulatory and adhesion molecules, thus rendering endothelial cells… CONTINUE READING