Alloantigen-specific CD4(+) regulatory T cells induced in vivo by ultraviolet irradiation after alloantigen immunization require interleukin-10 for their induction and activation, and flexibly mediate bystander immunosuppression of allograft rejection.

@article{Hori2015AlloantigenspecificCR,
  title={Alloantigen-specific CD4(+) regulatory T cells induced in vivo by ultraviolet irradiation after alloantigen immunization require interleukin-10 for their induction and activation, and flexibly mediate bystander immunosuppression of allograft rejection.},
  author={Tomohide Hori and Kagemasa Kuribayashi and Kanako Saito and Linan Wang and Mie Torii and Shinji Uemoto and Takuma Kato},
  journal={Transplant immunology},
  year={2015},
  volume={32 3},
  pages={
          156-63
        }
}
Ultraviolet (UV) irradiation prior to antigen immunization is employed to induce antigen-specific regulatory T cells (Tregs). UV-induced Tregs demonstrate unique bystander suppression, although antigen-specific activation is required initially. We previously reported the phenotype of alloantigen-specific transferable Tregs induced by UV-B irradiation after immunization was the same as T regulatory type 1-like CD4(+) T cells, with antigen-specific interleukin (IL)-10 production. Here, by using… CONTINUE READING
BETA

References

Publications referenced by this paper.
SHOWING 1-10 OF 57 REFERENCES

Milestones in photoimmunology.

  • The Journal of investigative dermatology
  • 2013
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

The Immunologic Revolution: Photoimmunology

  • The Journal of investigative dermatology
  • 2012
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Regulatory T cells and inflammatory bowel disease.

  • Immunology today
  • 1999
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Ultraviolet - radiation - induced in fl ammation promotes angiotropism and metastasis in melano

T Bald, T Quast, +3 authors D Lopez-Ramos
  • Nature
  • 2014

Similar Papers

Loading similar papers…