Alloantigen recognition by two human natural killer cell clones is associated with HLA-C or a closely linked gene.

@article{Colonna1992AlloantigenRB,
  title={Alloantigen recognition by two human natural killer cell clones is associated with HLA-C or a closely linked gene.},
  author={Marco Colonna and Thomas Spies and Jack Leonard Strominger and Ermanno 5 Ciccone and Alessandro Moretta and Daniela Pende and Oriane Viale},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 17},
  pages={7983-5}
}
Human natural killer (NK) cells with the CD3- CD16+ phenotype recognize allospecificities on normal T-cell blasts. The NK-defined specificity 1 (NK-1) is recessively inherited and has been mapped to the major histocompatibility complex between the complement gene cluster and HLA-A. A gene for NK-1, however, has not been identified. Here we demonstrate that NK-1 and the recently defined NK specificity 2 (NK-2) are reciprocally associated with homozygosity for a diallelic polymorphism at amino… CONTINUE READING
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