Alloantigen-induced, T-cell-dependent production of nitric oxide by macrophages infiltrating skin allografts in mice.

@article{Krulov2002AlloantigeninducedTP,
  title={Alloantigen-induced, T-cell-dependent production of nitric oxide by macrophages infiltrating skin allografts in mice.},
  author={Magdal{\'e}na Krulov{\'a} and Alena Zaj{\'i}cov{\'a} and Jan Fric and Vladimir Holan},
  journal={Transplant international : official journal of the European Society for Organ Transplantation},
  year={2002},
  volume={15 2-3},
  pages={108-16}
}
The immunological rejection reaction occurring after organ or tissue transplantation is characterized by a strong infiltration of the graft by T cells and macrophages. Since the rejection reaction is highly specific, we tested the role of T cells in the activation of macrophages and in the induction of nitric oxide (NO) production during graft rejection. The rejection of both MHC and non-MHC antigen-disparate skin allografts was associated with a significantly increased production of NO in the… CONTINUE READING