Alliin Attenuated RANKL-Induced Osteoclastogenesis by Scavenging Reactive Oxygen Species through Inhibiting Nox1

@inproceedings{Chen2016AlliinAR,
  title={Alliin Attenuated RANKL-Induced Osteoclastogenesis by Scavenging Reactive Oxygen Species through Inhibiting Nox1},
  author={Yueqi Chen and Jingjing Sun and Ce Dou and Nan Li and Fei Kang and Yuan Wang and Zhen Yuan Cao and Xiaochao Yang and Shiwu Dong},
  booktitle={International journal of molecular sciences},
  year={2016}
}
The healthy skeleton requires a perfect coordination of the formation and degradation of bone. Metabolic bone disease like osteoporosis is resulted from the imbalance of bone formation and/or bone resorption. Osteoporosis also reflects lower level of bone matrix, which is contributed by up-regulated osteoclast-mediated bone resorption. It is reported that monocytes/macrophage progenitor cells or either hematopoietic stem cells (HSCs) gave rise to multinucleated osteoclasts. Thus, inhibition of… CONTINUE READING

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