Allicin-inspired thiolated fluoroquinolones as antibacterials against ESKAPE pathogens.


Thiolated fluoroquinolones were synthesized from ciprofloxacin and evaluated for antimicrobial activity against a panel of pathogenic bacteria. Gram-positive species including methicillin-resistant Staphylococcus aureus (MRSA) exhibited the highest level of increased sensitivity toward ciprofloxacin bound with a N-propylthio substituent. Evidence was found… (More)
DOI: 10.1016/j.bmcl.2016.10.002


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