Allicin inhibits SDF-1alpha-induced T cell interactions with fibronectin and endothelial cells by down-regulating cytoskeleton rearrangement, Pyk-2 phosphorylation and VLA-4 expression.

@article{Sela2004AllicinIS,
  title={Allicin inhibits SDF-1alpha-induced T cell interactions with fibronectin and endothelial cells by down-regulating cytoskeleton rearrangement, Pyk-2 phosphorylation and VLA-4 expression.},
  author={Uri Sela and Sharon Ganor and Iris Hecht and Alexander Brill and Talia Miron and Aharon Rabinkov and Meir Wilchek and David Mirelman and Ofer Lider and Rami Hershkoviz},
  journal={Immunology},
  year={2004},
  volume={111 4},
  pages={391-9}
}
Allicin, a major ingredient of fresh garlic extract that is produced during the crushing of garlic cloves, exerts various beneficial biological effects, including a broad spectrum of antimicrobial activity, antihyperlipidaemic and antihypertensive effects. However, how allicin affects the immune system is less well known, and its effect on human T cells has never been studied. Here, we examined the in-vitro effects of allicin on the functioning of T cells related to their entry to inflamed… CONTINUE READING

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