Allicin, a naturally occurring antibiotic from garlic, specifically inhibits acetyl-CoA synthetase.

@article{Focke1990AllicinAN,
  title={Allicin, a naturally occurring antibiotic from garlic, specifically inhibits acetyl-CoA synthetase.},
  author={Manfred Focke and Andrew D Feld and K Lichtenthaler},
  journal={FEBS letters},
  year={1990},
  volume={261 1},
  pages={106-8}
}
Allicin is shown to be a specific inhibitor of the acetyl-CoA synthetases from plants, yeast and mammals. The bacterial acetyl-CoA-forming system, consisting of acetate kinase and phosphotransacetylase, was inhibited too. Non-specific interaction with sulfhydryl-groups could be excluded in experiments with dithioerythritol and p-hydroxymercuribenzoate. Binding of allicin to the enzyme is non-covalent and reversible. [14C]-Acetate incorporation into fatty acids of isolated plastids was inhibited… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

Similar Papers

Loading similar papers…