Alleviative effects of fluoxetine on depressive-like behaviors by epigenetic regulation of BDNF gene transcription in mouse model of post-stroke depression

@inproceedings{Jin2017AlleviativeEO,
  title={Alleviative effects of fluoxetine on depressive-like behaviors by epigenetic regulation of BDNF gene transcription in mouse model of post-stroke depression},
  author={Hui-juan Jin and Lei Pei and Ya-nan Li and Hui Zheng and Shuai Yang and Yan Wan and Ling Mao and Yuan-peng Xia and Quan-wei He and Man Rong Li and Zhen-yu Yue and Bo Hu},
  booktitle={Scientific Reports},
  year={2017}
}
Fluoxetine, one of the selective serotonin reuptake inhibitor (SSRI) antidepressants, has been thought to be effective for treating post-stroke depression (PSD). Recent work has shown that fluoxetine may exert an antidepressive effect through increasing the level of brain-derived neurotrophic factor (BDNF), but the underlying mechanism still remains unclear. In the present study, we successfully established the PSD model using male C57BL/6 J mice by photothrombosis of the left anterior cortex… CONTINUE READING
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