Alleviation of restriction by DNA condensation and non-specific DNA binding ligands.

@article{Keatch2004AlleviationOR,
  title={Alleviation of restriction by DNA condensation and non-specific DNA binding ligands.},
  author={Steven A. Keatch and Tsueu-Ju Su and David T. F. Dryden},
  journal={Nucleic acids research},
  year={2004},
  volume={32 19},
  pages={5841-50}
}
During conditions of cell stress, the type I restriction and modification enzymes of bacteria show reduced, but not zero, levels of restriction of unmethylated foreign DNA. In such conditions, chemically identical unmethylated recognition sequences also occur on the chromosome of the host but restriction alleviation prevents the enzymes from destroying the host DNA. How is this distinction between chemically identical DNA molecules achieved? For some, but not all, type I restriction enzymes… CONTINUE READING