Alleviation of renal mitochondrial dysfunction and apoptosis underlies the protective effect of sitagliptin in gentamicin-induced nephrotoxicity.

@article{Abuelezz2016AlleviationOR,
  title={Alleviation of renal mitochondrial dysfunction and apoptosis underlies the protective effect of sitagliptin in gentamicin-induced nephrotoxicity.},
  author={Sally A. Abuelezz and Nevien Hendawy and Sara Abdel Gawad},
  journal={The Journal of pharmacy and pharmacology},
  year={2016},
  volume={68 4},
  pages={523-32}
}
OBJECTIVE This study aimed to investigate the potential protective effect of sitagliptin on gentamicin-induced nephrotoxicity and to elucidate the underlying mechanism. METHODS Wistar rats were allocated as follows: Gentamicin group: received gentamicin intraperitoneally (100 mg/kg/day); Gentamicin plus sitagliptin group: received simultaneous gentamicin and sitagliptin (30 mg/kg/day orally); Sitagliptin group: received only sitagliptin; and CONTROL GROUP received saline. Blood urea… CONTINUE READING