Alleviation of jet lag by melatonin: preliminary results of controlled double blind trial.

  title={Alleviation of jet lag by melatonin: preliminary results of controlled double blind trial.},
  author={Jos{\'e}phine Arendt and M. E. Aldhous and Vincent Marks},
  journal={British Medical Journal (Clinical research ed.)},
  pages={1170 - 1170}
Jet lag is an ill defined phenomenon resulting from rapid flight across several time zones.' It is considered to be due to desynchronisation of circadian rhythms, such as the sleep-wake cycle, with local time and to lack of sleep. ' A means of rapidly resynchronising body rhythms to local time would benefit people who suffer badly from jet lag. Various remedies for alleviating jet lag have been proposed: manipulation of dietary intake and, more recently, appropriate exposure to'bright light… 

Managing jet lag: Some of the problems and possible new solutions.

  • J. Arendt
  • Psychology, Biology
    Sleep medicine reviews
  • 2009

Approaches to the Pharmacological Management of Jet Lag

This review covers the relatively new chronobiotic drugs, which can hasten adaptation of the circadian system, together with drugs directly affecting alertness and sleep propensity, and the melatoninergic drugs are promising but larger trials in real-life situations are needed.

Melatonin for the prevention and treatment of jet lag.

Melatonin is remarkably effective in preventing or reducing jet-lag, and occasional short-term use appears to be safe, and should be recommended to adult travellers flying across five or more time zones, particularly in an easterly direction, and especially if they have experienced jet- lag on previous journeys.

Effect of melatonin on jet lag after long haul flights.

Melatonin can alleviate jet lag and tiredness after long haul flights and was more severe on the return (westward) than the outward (eastward) journey.

Jet Lag: Use of Melatonin and Melatonergic Drugs

The therapeutic values of melatonin and its agonists such as ramelteon in reducing the jet lag symptoms and use of the melatonergic antidepressant, agomelatine, for jet lag-associated depressive disorders are discussed in this chapter.

Clinical practice. Jet lag.

  • R. Sack
  • Psychology
    The New England journal of medicine
  • 2010
The symptoms of jet lag consist primarily of insomnia and daytime sleepiness but can also include dysphoric mood, diminished physical performance, cognitive impairment, and gastrointestinal disturbances.

Effect of 3 mg melatonin on jet lag syndrome in an 8‐h eastward flight

Melatonin accelerated the rate of the re‐entrainment of the circadian melatonin rhythm and was useful to jet travel from Tokyo to Los Angeles.

Management of Circadian Desynchrony (Jetlag and Shiftlag) in CF Air Operations

This report presents the highlights of a 4-year project to optimize CF ability to manipulate circadian rhythms forwards or backwards to counter jetlag and shiftlag, and offers recommendation for exploitation of this new capability to sustain operational readiness.



Free-running activity rhythms in the rat: entrainment by melatonin.

The pineal gland hormone melatonin may play a role in synchronization of rat circadian rhythms, and the time of day of melatonin administration is crucial in pharmacological experiments.

Physiological changes underlying jet lag.

If the present promising results with cognitive therapy are confirmed they will have implications for a wi& range of training schemes, and will once more direct the authors' attention to psychological treatments for psychological disorders.

Can melatonin alleviate jet lag?