Alleviation of jet lag by melatonin: preliminary results of controlled double blind trial.

@article{Arendt1986AlleviationOJ,
  title={Alleviation of jet lag by melatonin: preliminary results of controlled double blind trial.},
  author={Jos{\'e}phine Arendt and M. E. Aldhous and Vincent Marks},
  journal={British Medical Journal (Clinical research ed.)},
  year={1986},
  volume={292},
  pages={1170 - 1170}
}
Jet lag is an ill defined phenomenon resulting from rapid flight across several time zones.' It is considered to be due to desynchronisation of circadian rhythms, such as the sleep-wake cycle, with local time and to lack of sleep. ' A means of rapidly resynchronising body rhythms to local time would benefit people who suffer badly from jet lag. Various remedies for alleviating jet lag have been proposed: manipulation of dietary intake and, more recently, appropriate exposure to'bright light… 

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...

References

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Free-running activity rhythms in the rat: entrainment by melatonin.

TLDR
The pineal gland hormone melatonin may play a role in synchronization of rat circadian rhythms, and the time of day of melatonin administration is crucial in pharmacological experiments.

Physiological changes underlying jet lag.

TLDR
If the present promising results with cognitive therapy are confirmed they will have implications for a wi& range of training schemes, and will once more direct the authors' attention to psychological treatments for psychological disorders.

Can melatonin alleviate jet lag?