Alleviation of ischemia-reperfusion injury in rat liver transplantation by induction of small interference RNA targeting Fas

@article{Li2006AlleviationOI,
  title={Alleviation of ischemia-reperfusion injury in rat liver transplantation by induction of small interference RNA targeting Fas},
  author={Xiu-ying Li and Jian Zhang and Ming Qi Lu and Yuan Li Yang and Chengyan Xu and Hongmei Li and George C. S. Wang and Chun Jie Cai and Gina H Chen},
  journal={Langenbeck's Archives of Surgery},
  year={2006},
  volume={392},
  pages={345-351}
}
BackgroundCellular apoptosis plays an important role in ischemia-reperfusion (I/R) injury during organ transplantation. Synthetic small interference RNA (siRNA) targeting apoptotic receptor Fas has proven effective to protect mice against hepatitis and renal I/R injury. The objective of this study is to investigate the silencing impact of Fas siRNA to alleviate I/R injury in rat liver transplantation.Materials and methodsRat hepatocytes (BRL cells) were transfected with three pairs of… CONTINUE READING
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