Alleviation of insulitis and moderation of diabetes in NOD mice following treatment with a synthetic Pseudomonas aeruginosasignal molecule, N-(3-oxododecanoyl)-L-homoserine lactone

@article{Pritchard2005AlleviationOI,
  title={Alleviation of insulitis and moderation of diabetes in NOD mice following treatment with a synthetic Pseudomonas aeruginosasignal molecule, N-(3-oxododecanoyl)-L-homoserine lactone},
  author={David Idris Pritchard and Ian Todd and Alexia Brown and Barrie W. Bycroft and Siri Ram Chhabra and Paul D. Williams and Philip B Wood},
  journal={Acta Diabetologica},
  year={2005},
  volume={42},
  pages={119-122}
}
Quorum sensing signal molecules (QSSMs) from the bacterium Pseudomonas aeruginosa control bacterial population density and the expression of virulence determinants. Coincidentally, and possibly to allow this pathogen to gain a foothold in the human body, certain signal molecules also downregulate immunological responses in an apparently T-helper 1-selective manner, which would suggest their application as therapeutics to some autoimmune diseases. In the present paper, experiments are described… CONTINUE READING

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Bacterial quorum sensing molecules as immune modulators. In: Henderson B, Oyston PCF (eds) Bacterial evasion of host immune responses. Advances in molecular and cellular microbiology

  • DI Pritchard, D Hooi, +8 authors P Williams
  • 2003
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Bacterial quorum sensing molecules as immune modulators

  • DI Pritchard, D Hooi, +8 authors P Williams
  • 2003

onset in NOD mice

  • L Weiss, V Barak, +6 authors S Slavin
  • 2002

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