Alleviation of graft-versus-host disease after conditioning with cobalt-protoporphyrin, an inducer of heme oxygenase-1.

@article{Woo2000AlleviationOG,
  title={Alleviation of graft-versus-host disease after conditioning with cobalt-protoporphyrin, an inducer of heme oxygenase-1.},
  author={Jeong-taek Woo and Suhasani Iyer and Naoyoshi Mori and Roland Buelow},
  journal={Transplantation},
  year={2000},
  volume={69 4},
  pages={623-33}
}
BACKGROUND Recently, we demonstrated that elevated expression of heme oxygenase-1 (HO-1 or Hsp-32) resulted in the modulation of several immune effector functions. Here we evaluated whether induction of HO-1 after administration of cobalt protoporphyrin (CoPP) can prevent the development of acute graft-versus-host-disease (GVHD). METHODS Acute GVHD was initiated by injection of unfractionated spleen cells from C57BL/6 into B6D2/F1 mice. RESULTS Administration of CoPP resulted in increased… CONTINUE READING
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