Alleviation of fatty acid and hypoxia-reoxygenation-induced proximal tubule deenergization by ADP/ATP carrier inhibition and glutamate.

@article{Feldkamp2007AlleviationOF,
  title={Alleviation of fatty acid and hypoxia-reoxygenation-induced proximal tubule deenergization by ADP/ATP carrier inhibition and glutamate.},
  author={Thorsten Feldkamp and Andreas Kribben and Nancy F. Roeser and Tiffany Ostrowski and Joel M. Weinberg},
  journal={American journal of physiology. Renal physiology},
  year={2007},
  volume={292 5},
  pages={F1606-16}
}
Kidney proximal tubules develop a severe but highly reversible energetic deficit due to nonesterified fatty acid (NEFA)-induced dissipation of mitochondrial membrane potential (DeltaPsi(m)) during reoxygenation after severe hypoxia. To assess the mechanism for this behavior, we have compared the efficacies of different NEFA for inducing mitochondrial deenergization in permeabilized tubules measured using safranin O uptake and studied the modification of NEFA-induced deenergization by inhibitors… CONTINUE READING