Alleviation of enhanced oxidative stress and oxygen consumption of L-thyroxine induced hyperthyroid rat liver mitochondria by vitamin E and curcumin.

@article{Subudhi2008AlleviationOE,
  title={Alleviation of enhanced oxidative stress and oxygen consumption of L-thyroxine induced hyperthyroid rat liver mitochondria by vitamin E and curcumin.},
  author={Umakanta Subudhi and Kajari Das and Biswaranjan Paital and Shravani Bhanja and Gagan Bihari Nityananda Chainy},
  journal={Chemico-biological interactions},
  year={2008},
  volume={173 2},
  pages={105-14}
}
In the present study, the role of vitamin E and curcumin on hyperthyroidism induced mitochondrial oxygen consumption and oxidative damage to lipids and proteins of rat liver are reported. Adult male rats were rendered hyperthyroid by administration of 0.0012% l-thyroxine in their drinking water, while vitamin E (200 mg/kg body weight) and curcumin (30 mg/kg body weight) were supplemented orally for 30 days. Hyperthyroidism induced elevation in serum aspartate aminotransferase and alanine… CONTINUE READING