Alleviating neurodegeneration by an anticancer agent: an Hsp90 inhibitor (17-AAG).

@article{Waza2006AlleviatingNB,
  title={Alleviating neurodegeneration by an anticancer agent: an Hsp90 inhibitor (17-AAG).},
  author={Masahiro Waza and Hiroaki Adachi and Masahisa Katsuno and Makoto Minamiyama and Fumiaki Tanaka and Gen Sobue},
  journal={Annals of the New York Academy of Sciences},
  year={2006},
  volume={1086},
  pages={21-34}
}
Heat shock proteins (HSPs) that function mainly as molecular chaperones play an important role in the folding and quality control of proteins. Compared with these chaperones, Hsp90 is unique in that it binds to substrate proteins, called Hsp90 client proteins. Hsp90 is involved in the folding, activation, and assembly of its client proteins in association with its co-chaperones. Because numerous oncoproteins belonging to the Hsp90 client protein family are selectively degraded by Hsp90… CONTINUE READING

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