Allergy to cocamidopropyl betaine may be due to amidoamine: a patch test and product use test study

  title={Allergy to cocamidopropyl betaine may be due to amidoamine: a patch test and product use test study},
  author={Joseph F. Fowler and Lynn M. Fowler and Judith E Hunter},
  journal={Contact Dermatitis},
Cocamidopropyl betaine (CAPB) is an amphoteric surfactant commonly used in personal care products and surface cleaners. Patch testing with commercially‐available CAPB has yielded occasional reactions indicative of allergic contact dermatitis. To determine if subjects with previous positive patch tests would react in provocative use tests of products containing CAPB, and to study various contaminants in commercial CAPB supplies for allergenicity in these subjects. 10 subjects previously positive… 
Provocative use tests in CAPB‐allergic subjects with CAPB‐containing product
The study confirmed thatCAPB‐sensitive individuals can use a CAPB‐based rinse‐off product without the risk of experiencing an allergic reaction to CAPB, as well as uncontrolled use testing with the shower gel.
Clinical allergy to cocamidopropyl betaine: reactivity to cocamidopropylamine and lack of reactivity to 3‐dimethylaminopropylamine
Results suggest that DMAPA is unlikely to be an important contact allergen in CAPB of appropriate quality and confirm thatCAPB of suitable purity, where levels of both cocamidopropylamine andDMAPA are minimized, is likely to trigger reactions in those ostensibly allergic to the material.
Cutaneous Delayed-Type Hypersensitivity to Surfactants
This study reports the frequency of positive patch test results to surfactants tested on the North American Contact Dermatitis Group screening series including cocamidopropyl betaine (CAPB), amidoamine (AA), dimethylaminopropylamine (DMAPA), OPD, and cocamide diethanolamide (CDEA), and correlations of positive reactions between CAPB and the other surfactant.
The allergen cocamidopropyl betaine
The authors’ overall assessment design was an involved procedure by elimination, which lasted over 6 weeks, required many successive challenges in the patients, and featured a progressive drop in the population such as to result in a statistically irrelevant final sample.
The role of 3‐dimethylaminopropylamine and amidoamine in contact allergy to cocamidopropylbetaine
It is hypothesized that DMAPA is in fact the true sensitizing substance, while amidoamine, which may in any case releaseDMAPA in vivo as a result of enzymatic hydrolysis, may favour the transepidermal penetration of the sensitizing agent.
Lack of patch test reactivity to 3‐dimethylaminopropylamine in German hairdressers
  • W. Uter
  • Chemistry
    Contact dermatitis
  • 1999
3-dimethylaminopropylamine (DMAPA, N,N-dimethylpropyl-1,3-diamine, CAS 109-55-7) is a raw material in the synthesis of cocamidopropylbetaine (CAPB), a detergent widely used in shampoo. Angelini et
Cocamidopropyl betaine.
Eyelid Dermatitis: Contact Allergy to 3‐(Dimethylamino)propylamine
A 42‐year‐old woman with intractable eyelid dermatitis is presented with sensitization to 3‐(dimethylamino)propylamine (DMAPA), an important etiology of allergic contact dermatitis of the eyelids and face but is easily missed even with expanded‐series patch testing.
Epidemiology and Co-Reactivity of Novel Surfactant Allergens: A Double-Blind Randomized Controlled Study
Isostearamidopropyl morpholine lactate may be an important emerging allergen with sensitivity rates comparable with those of oleamido-dimethylamine and dimethylaminopropylamine, and co-reactivity among surfactants was frequent except for cocamide DEA.
Allergic contact dermatitis to cocamidopropyl betaine in Colombia
The second symposium on the definition and Management of anaphylaxis and the risk for Cardiopulmonary Adverse Events and Epidemiology of life-threatening and lethal anaphYLaxis: a review was held in Washington, DC.


3‐Dimethylaminopropylamine: a key substance in contact allergy to cocamidopropylbetaine?
The results suggest that the DMPA present at various levels as an impurity in the commercial product is responsible for cocamidopropylbetaine allergy.
Cocamidopropyl betaine: the significance of positive patch test results in twelve patients.
It is concluded that although cocamidopropyl betaine is not a common allergen, it may be at least partially responsible for some cases of allergic dermatitis of the head and neck.
Eyelid dermatitis due to cocamidopropyl betaine in a hard contact lens solution
Patch test with Zineryt® lotion was negative, but a ROAT was strongly positive, and her face became erythromatous and itchy, and controls were negative to the highest test concentrations of di-isopropyl, diethyl and dibutyl sebacate.
Contact allergy to cocamidopropyl betaine (CAPB)
4. Raulin C, Frosch P J, Green C A, Farr P M, Shuster S, Veraldi S, Schianchi-Veraldi R.
Shampoo dermatitis due to cocobetaine and sodium lauryl ether sulphate
The dermatitis cleared when the patient changed to a shampoo with a sodium Iaury! ether sulphate base with sorbic acid as the preservative.
Shampoo dermatitis due to cocamidopropyl betaine
A 22-year-old male hairdresser, with no family or personal history of atopy, presented with erythematous swelling lesions on his hands, fingers and forearms. Complete blood and urine hematochemical
Contact dermatitis from cocamidopropyl betaine
4 women were positive to cocamidopropyl betaine (CPB) 1.0% aq.
Eyelid dermatitis due to cocamidopropyl betaine in an eye make‐up remover
A 60-year-old woman had a 2-month history of eyelid eczema, with no personal or family history of atopy. Patch testing to the European standard series, a series of facial allergens, and her own
Tegobetaine in contact lens solutions
The fact that patients with contact dermatitis from propolis are not always sensit1ve to balsam of Peru (2, 7, 8, 10, I 1) may be related to propolis' differmg composition according to its.
Contact dermatitis to cocamidopropyl-betaine is caused by residual amines: relevance, clinical characteristics and review of the literature
  • Am J Contact Dermatitis
  • 1995