Allergy to betalactams and nucleotide-binding oligomerization domain (NOD) gene polymorphisms.

  title={Allergy to betalactams and nucleotide-binding oligomerization domain (NOD) gene polymorphisms.},
  author={Anne Claire Bursztejn and Antonio Romano and Rosa-Maria Gu{\'e}ant-Rodr{\'i}guez and Jose A. Cornejo and Abderrahim Oussalah and C{\'e}line Ch{\'e}ry and Isabelle Gastin and Francesco Saverio Gaeta and Annick Barbaud and Miguel Blanca and Jean-Louis Gu{\'e}ant},
  volume={68 8},
BACKGROUND Polymorphisms of interleukin genes related to IgE production and inflammation are predictors of hypersensitivity to betalactam, but nothing is known on the influence of NOD genes, despite their association with inflammation and atopy. OBJECTIVE To evaluate the association of NOD2 and NOD1 polymorphisms with betalactam allergy. METHOD We genotyped 3 polymorphisms of NOD2 and 1 of NOD1 in 368 Italian and 387 Spanish patients, compared with 368 and 326 controls, respectively… CONTINUE READING
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