Allergy to Mammalian Proteins: At the Borderline between Foreign and Self?

  title={Allergy to Mammalian Proteins: At the Borderline between Foreign and Self?},
  author={Susanne Spitzauer},
  journal={International Archives of Allergy and Immunology},
  pages={259 - 269}
  • S. Spitzauer
  • Published 1 December 1999
  • Biology
  • International Archives of Allergy and Immunology
Atopic individuals are characterized by their genetically determined tendency to mount IgE antibody responses against otherwise harmless antigens. Many of the environmental allergens (e. g., plant–, insect–, mould–derived allergens) are recognized as foreign intruders by the immune system. However, a substantial proportion of atopic individuals mount IgE responses to allergens of mammalian origin and, as recently reported, certain of them even react with human proteins (i. e., autoallergens… 

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