Allergies: Their Role in Cancer Prevention

  title={Allergies: Their Role in Cancer Prevention},
  author={Paul W. Sherman and Erica Holland and Janet Shellman Sherman},
  journal={The Quarterly Review of Biology},
  pages={339 - 362}
The nature of the biological relationships between cancers and allergies has intrigued researchers and health care providers for five decades. Three hypotheses have been proposed: antigenic stimulation predicts positive associations between cancers and allergies (i.e., allergy sufferers are more likely to get cancer), whereas immunosurveillance and prophylaxis predict inverse associations (i.e., allergy sufferers are less likely to get cancer). Immunosurveillance predicts inverse associations… 

Epidemiological associations of allergy, IgE and cancer

This review summarizes and draws conclusions from the epidemiological literature examining the relationships between specific types of cancer and allergic diseases, and proposes adding a fourth hypothesis: inappropriate T‐helper 2 (Th2) immune skewing.

Allergies: diseases closely related to cancer.

Allergy-Related Diseases and Risk of Breast Cancer: The Role of Skewed Immune System on This Association

The pattern of the results from most studies indicated that allergic diseases might be associated with an increased risk of BC, andwed immune system toward T-helper 2 might have an important role in this association.

Association between cancer and allergies

The results indicate that the overall incidence of allergies, particularly allergic rhinitis, was lower in patients with some types of cancer.

Systems Immunology Approach in Understanding the Association of Allergy and Cancer

The association of atopic allergy with different types of cancer, and the key immune cells and important molecules associated with both the diseases have been highlighted and the future perspectives of the field of allergo-oncology and possible therapeutic approaches to modulate the immune systems have been described.

Allergies and Asthma in Relation to Cancer Risk

While asthma wasassociated with increased lung cancer risk, history of allergies was associated with decreased risk, an association driven by an inverse association among non-Hispanic whites.

A history of allergies is associated with reduced risk of oral squamous cell carcinoma

There is an inverse association between history of allergies to dust, pollen, or mold and OSCC, whether the inverse association involves heightened immune surveillance, increased immune response to HPV or other antigen, or other carcinogenic mechanism remains to be determined in more definitive studies.

Current status and perspectives regarding the association between allergic disorders and cancer

The aim of current review was to summarize the current knowledge of the association between allergic diseases and the risk of cancers with particular emphasis on case–controls and cohort studies to estimate the cancer risk associated with allergy.

Epidemiology: allergy history, IgE, and cancer

  • M. Turner
  • Medicine, Biology
    Cancer Immunology, Immunotherapy
  • 2011
This paper summarizes the recent epidemiological literature examining associations between allergy history and cancer risk and potential methodological sources of bias are discussed as well as recommendations for future work.

Risk of Cervical Cancer Associated with Allergies and Polymorphisms in Genes in the Chromosome 5 Cytokine Cluster

Pollen allergy was directly related to pollen allergies in controls and to reduced SCC risk, and the mechanism behind allergy-associated immune response associated with S CC risk may be worth exploring in the context of therapeutic or prophylactic vaccines.



The association between allergies and cancer: what is currently known?

Allergy-related diseases and cancer: an inverse association.

The findings suggest that individuals with allergy-related disorders may be at decreased risk of cancer, although reasons for cautious interpretation of the findings are emphasized.

Allergy and cancer: organ site-specific results from the Adventist Health Study.

The association between allergy and cancer is complex and depends on the specific allergy and the specific organ site under consideration, as was the case in the cohort study of Seventh-day Adventists in California.

Atopic diseases, immunoglobulin E and risk of cancer of the prostate, breast, lung and colorectum

The findings are consistent with other epidemiological evidence suggesting an increased risk of prostate cancer with atopy and indicate a complex association between atopy/atopy‐related diseases and cancer risk that varies by type of atopy‐ related disorders and the particular type of cancer under consideration.

Allergies and the Risk of Pancreatic Cancer: A Meta-analysis with Review of Epidemiology and Biological Mechanisms

Allergies, in particular those related to atopy, seem to be associated with a decreased risk of pancreatic cancer, and the hyperactive immune system of allergic individuals may, therefore, in some way lead to increased surveillance and protect against pancreaticcancer development.

Allergy, atopy, and cancer: a prospective study of the 1981 Busselton cohort.

History of asthma and hay fever were associated with a trend toward a reduced risk of colorectal cancer and increased risk of leukemia, but these results were not statistically significant.

Comparative Incidence of Allergy in the Presence or Absence of Cancer

The results suggest that allergies occur more frequently in men than in women and less frequently in patients with cancer than in healthy controls but these relationships are complex and depend on other factors that need further investigation.

An overview of the association between allergy and cancer

An overview of the epidemiological evidence is presented with a discussion of a number of methodological issues important in this area of study, including the validity and reliability of exposure measures and control for confounding.

Allergy and risk of cancer. A prospective study using nhanesi followup data

It is suggested that a history of allergy does not protect against subsequent cancer, and may be a risk factor for lymphatic‐hematopoietic malignancies.

Mechanisms of Disease: the hygiene hypothesis revisited

The use of probiotics, prebiotics, helminths or microbe-derived immunoregulatory vaccines might, therefore, become a valuable approach to disease prevention.