Allergic skin sensitization promotes eosinophilic esophagitis through the IL-33-basophil axis in mice.

@article{Venturelli2016AllergicSS,
  title={Allergic skin sensitization promotes eosinophilic esophagitis through the IL-33-basophil axis in mice.},
  author={Nicholas Venturelli and Willem S. Lexmond and Asa Ohsaki and S Nurko and Hajime Karasuyama and Edda Fiebiger and Michiko K Oyoshi},
  journal={The Journal of allergy and clinical immunology},
  year={2016},
  volume={138 5},
  pages={
          1367-1380.e5
        }
}
BACKGROUND Eosinophilic esophagitis (EoE) is an allergic inflammatory disorder characterized by accumulation of eosinophils in the esophagus. EoE often coexists with atopic dermatitis, a chronic inflammatory skin disease. The impaired skin barrier in patients with atopic dermatitis has been suggested as an entry point for allergic sensitization that triggers development of EoE. OBJECTIVE We sought to define the mechanisms whereby epicutaneous sensitization through a disrupted skin barrier… CONTINUE READING
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