Allergic rhinitis and polymorphisms of the interleukin 1 gene complex.

  title={Allergic rhinitis and polymorphisms of the interleukin 1 gene complex.},
  author={Veli-Pekka Joki-Erkkil{\"a} and Jussi Karjalainen and Janne Hulkkonen and Tanja Pessi and Markku M. Nieminen and Arpo R J Aromaa and Timo Klaukka and Mikko A. Hurme},
  journal={Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology},
  volume={91 3},
BACKGROUND Allergic rhinitis is a chronic inflammatory disease with a genetic background. Inflammatory reactions are regulated by cytokines. Cytokine genes are polymorphic and have been implicated as candidate genes in allergy. OBJECTIVES To study the significance of the interleukin 1 (IL-1) gene complex in allergic rhinitis. METHODS Population-based, cross-sectional study. We studied the polymorphisms of 3 IL-1 gene complex genes, IL1A (+4845G>T), IL1B (-511 degrees C>T), and IL1RN… CONTINUE READING
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