Allergic rhinitis and its pharmacology.

@article{AlSuleimani2007AllergicRA,
  title={Allergic rhinitis and its pharmacology.},
  author={Yousuf M. Al Suleimani and Michael J A Walker},
  journal={Pharmacology \& therapeutics},
  year={2007},
  volume={114 3},
  pages={
          233-60
        }
}
The pathophysiology of allergic rhinitis and its drug treatment is reviewed. Special emphasis is placed upon potential new treatments. Allergic rhinitis is characterized by allergen(s), symptoms (sneezing, itching, rhinorrhea, nasal congestion and nasal hypersensitivity), and signs such as invasion of nasal mucosa by inflammatory cells. Such pathological changes are due to inflammatory responses mediated by way of allergen-immunoglobulin E (IgE)-cell complex formation. The complexity of the… Expand
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References

SHOWING 1-10 OF 399 REFERENCES
Unique mechanistic features of allergic rhinitis.
  • A. Togias
  • Medicine
  • The Journal of allergy and clinical immunology
  • 2000
TLDR
Evidence exists that the neurotrophin nerve growth factor, which can induce all these changes on sensory nerves, is produced in the human nasal mucosa and found in higher quantities in nasal secretions of patients with perennial allergic rhinitis as compared with healthy control subjects. Expand
Pathogenesis of allergic rhinitis.
  • J. Baraniuk
  • Medicine
  • The Journal of allergy and clinical immunology
  • 1997
TLDR
Understanding of the basic pathophysiologic features of allergic rhinitis continues to increase, the development of new diagnostic and treatment strategies may allow more effective modulation of the immune system, the atopic disease process, and the associated morbidity. Expand
Rhinitis and asthma : similarities and differences
TLDR
This book presents rhinitis and asthma research together to give an integrated review of current knowledge of the two diseases, both of which occur in the airway mucous membrane and which have similar pathophysiology. Expand
Hyperresponsiveness in the human nasal airway: new targets for the treatment of allergic airway disease.
TLDR
Evidence obtained from both animal models and in vivo experiments in humans indicate that some mediators may interact with one another, resulting in AHR, and further research into these interactions may open new avenues for the pharmacological treatment of chronic allergic rhinitis, and possibly other allergic airway diseases. Expand
Allergy and allergic diseases. Second of two parts.
  • A. B. Kay
  • Medicine
  • The New England journal of medicine
  • 2001
[Oral second generation antihistamines in allergic rhinitis].
TLDR
Oral second generation antihistamines are particularly useful for the treatment of less severe intermittent forms of nasal allergy due to their minimal adverse effects and efficient symptom reduction. Expand
Allergic rhinitis: not purely a histamine‐related disease
Allergic rhinitis is an inflammatory disorder of the nasal mucosa typified by the symptoms of nasal itch, sneeze, anterior nasal secretions, and nasal blockage. These symptoms arise from theExpand
New targets for allergic rhinitis — a disease of civilization
TLDR
Blockade of IgE, using monoclonal antibodies and vaccine strategies, is a new approach for interrupting the allergic cascade, whereas the use of recombinant mutated allergens, peptides and DNA oligonucleotides will lead to improved efficacy and reduced side effects of immunotherapy to induce tolerance. Expand
A new model of allergic rhinitis in rats by topical sensitization and evaluation of H(1)-receptor antagonists.
TLDR
A chronic allergic rhinitis model showing nasal symptoms in rats is developed, and this model may be useful for evaluating the effects of drugs on allergicrhinitis. Expand
Pathophysiology of allergic rhinitis.
TLDR
The mechanisms of allergic rhinitis have been clarified using nasal challenge with allergen or proinflammatory mediators and measuring cells and mediators released during the early- and late-phase allergic reaction. Expand
...
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2
3
4
5
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