Allergic reactions to the first COVID‐19 vaccine: A potential role of polyethylene glycol?

@article{Cabanillas2020AllergicRT,
  title={Allergic reactions to the first COVID‐19 vaccine: A potential role of polyethylene glycol?},
  author={Beatriz Cabanillas and Cezmi A. Akdis and Natalija Novak},
  journal={Allergy},
  year={2020},
  volume={76}
}
The COVID-19 vaccine developed by Pfizer and BioNTech was approved by the Medicines and Healthcare Products Regulatory Agency (MHRA) in the United Kingdom (UK) on December 2nd 2020.1 MHRA is therefore the first regulator agency in the world to approve a vaccine to prevent coronavirus disease (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a virus that is responsible for a global pandemic. 
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This issue of Allergy features articles with current information on allergy‐related questions regarding COVID‐19 vaccination. Expand
COVID‐19 vaccines and the role of other potential allergenic components different from PEG. A reply to: “Other excipients than PEG might cause serious hypersensitivity reactions in COVID‐19 vaccines”
To the Editor, Thank you for the correspondence of Borgsteede et al “Other excipients than PEG might cause serious hypersensitivity reactions in COVID19 vaccines.”1 We agree with the authors and… Expand
Anaphylactic reactions to mRNA COVID-19 vaccines: A call for further study
Several highly effective vaccines are available just over a year since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of coronavirus disease 2019… Expand
A Bullous Eruption following the Pfizer‐BioNTech COVID‐19 vaccination
On December 2nd,  2020 the Medicines and Healthcare products Regulatory Agency (MHRA) authorized use of a modRNA - nucleoside modified messenger RNA (mRNA) COVID-19 vaccine; Pfizer- BioNTech. Prior… Expand
Practical handling of allergic reactions to COVID-19 vaccines
TLDR
Recommendations for prophylaxis, diagnosis and therapy of these allergic reactions are given by a panel of experts, and allergy workup is recommended, as it is for a small potential risk population prior to the first vaccination. Expand
Who Is Really at Risk for Anaphylaxis Due to COVID-19 Vaccine?
The vaccination campaign against the Severe acute respiratory syndrome coronavirus 2 (Sars-Cov-2) started on 8 December 2020 in UK, after the approval of BNT162b2 by the Healthcare products… Expand
Adverse rare events to vaccines for COVID-19: From hypersensitivity reactions to thrombosis and thrombocytopenia
TLDR
An updated review of the last scientific findings that can explain the rare side effects that the vaccines for COVID-19 can produce is provided. Expand
Allergy to COVID-19 vaccines: A current update
TLDR
The different excipients in the vaccines with the potential to elicit systemic allergic reactions such as polyethylene glycol (PEG), polysorbates, tromethamine/trometamol, and others are described and the possible immunological mechanisms involved are described. Expand
ARIA‐EAACI statement on severe allergic reactions to COVID‐19 vaccines – An EAACI‐ARIA Position Paper
TLDR
The current data have not shown any higher risk for patients suffering from allergic rhinitis or asthma, and this message should be clearly stated by physicians to enable patients to trust the vaccine. Expand
mRNA Vaccines to Prevent COVID-19 Disease and Reported Allergic Reactions: Current Evidence and Suggested Approach
TLDR
This review summarizes vaccine allergy epidemiology and proposes drug and vaccine allergy expert opinion informed risk stratification for Allergy specialist use in conjunction with guidance of public health and regulatory authorities. Expand
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