Allergic reactions to the first COVID‐19 vaccine: A potential role of polyethylene glycol?

@article{Cabanillas2020AllergicRT,
  title={Allergic reactions to the first COVID‐19 vaccine: A potential role of polyethylene glycol?},
  author={Beatriz Cabanillas and Cezmi A. Akdis and Natalija Novak},
  journal={Allergy},
  year={2020},
  volume={76}
}
The COVID-19 vaccine developed by Pfizer and BioNTech was approved by the Medicines and Healthcare Products Regulatory Agency (MHRA) in the United Kingdom (UK) on December 2nd 2020.1 MHRA is therefore the first regulator agency in the world to approve a vaccine to prevent coronavirus disease (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a virus that is responsible for a global pandemic. 
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To the Editor, Thank you for the correspondence of Borgsteede et al “Other excipients than PEG might cause serious hypersensitivity reactions in COVID19 vaccines.”1 We agree with the authors and
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Practical handling of allergic reactions to COVID-19 vaccines
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COVID-19 Vaccine Anaphylaxis: Current Evidence and Future Approaches
  • W. Laisuan
  • Medicine, Biology
    Frontiers in Allergy
  • 2021
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Skin testing, using the basophil activation test, has been used to clarify the mechanism of the anaphylaxis and provide safety information for the next injection and suggested approaches for patients who experienced an immediate severe allergic reaction to the first dose of a COVID-19 vaccine.
Adverse rare events to vaccines for COVID-19: From hypersensitivity reactions to thrombosis and thrombocytopenia
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Potential life-threatening hypersensitivity reactions to hidden molecules like macrogol may be underdiagnosed and the awareness regarding the allergenic potential of PEG should be raised and a proper product labelling is crucial to prevent PEG mediated hypersensitivity.
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