Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells

  title={Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells},
  author={E. Jacobsen and S. Ochkur and R. Pero and A. Taranova and C. Protheroe and D. Colbert and N. Lee and J. Lee},
  journal={The Journal of Experimental Medicine},
  pages={699 - 710}
  • E. Jacobsen, S. Ochkur, +5 authors J. Lee
  • Published 2008
  • Biology, Medicine
  • The Journal of Experimental Medicine
  • The current paradigm surrounding allergen-mediated T helper type 2 (Th2) immune responses in the lung suggests an almost hegemonic role for T cells. Our studies propose an alternative hypothesis implicating eosinophils in the regulation of pulmonary T cell responses. In particular, ovalbumin (OVA)-sensitized/challenged mice devoid of eosinophils (the transgenic line PHIL) have reduced airway levels of Th2 cytokines relative to the OVA-treated wild type that correlated with a reduced ability to… CONTINUE READING
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