Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells

@article{Jacobsen2008AllergicPI,
  title={Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells},
  author={Elizabeth A. Jacobsen and Sergei I. Ochkur and Ralph S. Pero and Anna G. Taranova and Cheryl A. Protheroe and Dana C. Colbert and Nancy A. Lee and James Joseph Lee},
  journal={The Journal of Experimental Medicine},
  year={2008},
  volume={205},
  pages={699 - 710}
}
The current paradigm surrounding allergen-mediated T helper type 2 (Th2) immune responses in the lung suggests an almost hegemonic role for T cells. Our studies propose an alternative hypothesis implicating eosinophils in the regulation of pulmonary T cell responses. In particular, ovalbumin (OVA)-sensitized/challenged mice devoid of eosinophils (the transgenic line PHIL) have reduced airway levels of Th2 cytokines relative to the OVA-treated wild type that correlated with a reduced ability to… CONTINUE READING

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