Allergic fungal rhinosinusitis (AFRS) - more than a fungal disease?

  title={Allergic fungal rhinosinusitis (AFRS) - more than a fungal disease?},
  author={Tineke Dutre and Surayie Al Dousary and Nan Zhang and C Bachert},
Allergic fungal rhinosinusitis (AFRS) is characterized by the growth of fungi, mostly Aspergillus sp., in the paranasal sinuses together with the formation of nasal polyps, peanut-butter like “allergic mucin” with fungal hyphae and typical CT-findings, as well as increased serum total IgE and Aspergillus-specific IgE concentrations. We here hypothesize that the increase in serum total IgE is caused by the local symbiosis of Asp. sp. with Staphylococcus aureus, a germ which is known for the… CONTINUE READING