Allergic diseases: From bench to clinic - Contribution of the discovery of interleukin-5.

@article{Yanagibashi2017AllergicDF,
  title={Allergic diseases: From bench to clinic - Contribution of the discovery of interleukin-5.},
  author={Tsutomu Yanagibashi and Mitsuo Satoh and Yoshinori Nagai and Masamichi Koike and Kiyoshi Takatsu},
  journal={Cytokine},
  year={2017},
  volume={98},
  pages={59-70}
}
T helper 2 cells produce a number of cytokines including inteleukin (IL)-5, IL-4 and IL-13. Group 2 innate lymphoid cells (ILC2s) also produce IL-5 under sterile conditions. IL-5 is interdigitating homodimeric glycoprotein and a member of the four α helical bundle motifs conserved among hematopoietic cytokines. IL-5 exerts its effects on target cells via IL-5 receptor (IL-5R), composed of an IL-5R α and βc subunit. The membrane proximal proline-rich motif of the cytoplasmic domain of both IL-5R… CONTINUE READING
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