Allergic contact dermatitis--formation, structural requirements, and reactivity of skin sensitizers.

@article{Karlberg2008AllergicCD,
  title={Allergic contact dermatitis--formation, structural requirements, and reactivity of skin sensitizers.},
  author={A. T. Karlberg and Moa Andresen Bergstr{\"o}m and Anna B{\"o}rje and Kristina Luthman and J. Lars G. Nilsson},
  journal={Chemical research in toxicology},
  year={2008},
  volume={21 1},
  pages={53-69}
}
Contact allergy is caused by a wide range of chemicals after skin contact. Its clinical manifestation, allergic contact dermatitis (ACD), is developed upon repeated contact with the allergen. This perspective focuses on two areas that have yielded new useful information during the last 20 years: (i) structure-activity relationship (SAR) studies of contact allergy based on the concept of hapten-protein binding and (ii) mechanistic investigations regarding activation of nonsensitizing compounds… CONTINUE READING
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